diff --git a/packages/cli-platform-apple/src/commands/runCommand/__tests__/runOnSimulator.test.ts b/packages/cli-platform-apple/src/commands/runCommand/__tests__/runOnSimulator.test.ts
new file mode 100644
index 000000000..596de693b
--- /dev/null
+++ b/packages/cli-platform-apple/src/commands/runCommand/__tests__/runOnSimulator.test.ts
@@ -0,0 +1,103 @@
+import child_process from 'child_process';
+import fs from 'fs';
+import {IOSProjectInfo} from '@react-native-community/cli-types';
+import {Device} from '../../../types';
+import {runOnSimulator} from '../runOnSimulator';
+import {buildProject} from '../../buildCommand/buildProject';
+import installApp from '../installApp';
+import {FlagsT} from '../createRun';
+
+jest.mock('child_process');
+jest.mock('fs', () => ({existsSync: jest.fn()}));
+jest.mock('../../buildCommand/buildProject');
+jest.mock('../installApp');
+
+const xcodeProject: IOSProjectInfo = {
+  name: 'TestApp.xcworkspace',
+  path: '/path/to/TestApp.xcworkspace',
+  isWorkspace: true,
+};
+
+const simulator: Device = {
+  name: 'iPhone 15',
+  udid: 'AAAA-BBBB-CCCC',
+  state: 'Booted',
+  type: 'simulator',
+};
+
+const args = {} as FlagsT;
+const developerDir = '/Applications/Xcode.app/Contents/Developer';
+
+beforeEach(() => {
+  jest.clearAllMocks();
+  (buildProject as jest.Mock).mockResolvedValue('');
+  (installApp as jest.Mock).mockResolvedValue(undefined);
+  (child_process.execFileSync as jest.Mock).mockReturnValue(
+    `${developerDir}\n`,
+  );
+});
+
+test('opens Simulator.app with the device UDID when it exists', async () => {
+  (fs.existsSync as jest.Mock).mockImplementation((target) =>
+    String(target).endsWith('Simulator.app'),
+  );
+
+  await runOnSimulator(
+    xcodeProject,
+    'ios',
+    'Debug',
+    'TestApp',
+    args,
+    simulator,
+  );
+
+  expect(child_process.execFileSync).toHaveBeenCalledWith('open', [
+    `${developerDir}/Applications/Simulator.app`,
+    '--args',
+    '-CurrentDeviceUDID',
+    simulator.udid,
+  ]);
+});
+
+test('falls back to DeviceHub via devices:// deep link when Simulator.app is absent', async () => {
+  (fs.existsSync as jest.Mock).mockImplementation((target) =>
+    String(target).endsWith('DeviceHub.app'),
+  );
+
+  await runOnSimulator(
+    xcodeProject,
+    'ios',
+    'Debug',
+    'TestApp',
+    args,
+    simulator,
+  );
+
+  // DeviceHub registers the `devices://` URL scheme, which focuses the device by UDID.
+  expect(child_process.execFileSync).toHaveBeenCalledWith('open', [
+    `devices://device/open?id=${simulator.udid}`,
+  ]);
+  // The deep link replaces the Simulator.app `-CurrentDeviceUDID` argument.
+  expect(child_process.execFileSync).not.toHaveBeenCalledWith(
+    'open',
+    expect.arrayContaining(['-CurrentDeviceUDID']),
+  );
+});
+
+test('does not boot the simulator when it is already booted', async () => {
+  (fs.existsSync as jest.Mock).mockReturnValue(true);
+
+  await runOnSimulator(
+    xcodeProject,
+    'ios',
+    'Debug',
+    'TestApp',
+    args,
+    simulator,
+  );
+
+  expect(child_process.spawnSync).not.toHaveBeenCalledWith(
+    'xcrun',
+    expect.arrayContaining(['boot']),
+  );
+});
diff --git a/packages/cli-platform-apple/src/commands/runCommand/runOnSimulator.ts b/packages/cli-platform-apple/src/commands/runCommand/runOnSimulator.ts
index fd0484108..093ed6a4c 100644
--- a/packages/cli-platform-apple/src/commands/runCommand/runOnSimulator.ts
+++ b/packages/cli-platform-apple/src/commands/runCommand/runOnSimulator.ts
@@ -1,4 +1,6 @@
 import child_process from 'child_process';
+import fs from 'fs';
+import path from 'path';
 import {IOSProjectInfo} from '@react-native-community/cli-types';
 import {logger} from '@react-native-community/cli-tools';
 import {ApplePlatform, Device} from '../../types';
@@ -32,12 +34,34 @@ export async function runOnSimulator(
     .execFileSync('xcode-select', ['-p'], {encoding: 'utf8'})
     .trim();
 
-  child_process.execFileSync('open', [
-    `${activeDeveloperDir}/Applications/Simulator.app`,
-    '--args',
-    '-CurrentDeviceUDID',
-    simulator.udid,
-  ]);
+  // Xcode 27 replaces Simulator.app with DeviceHub.app and relocates it from
+  // <Xcode>/Contents/Developer/Applications to <Xcode>/Contents/Applications.
+  // Prefer Simulator.app while it exists (stable Xcode); fall back to DeviceHub
+  // for Xcode 27+. See https://developer.apple.com/documentation/xcode/device-hub
+  const simulatorApp = path.join(
+    activeDeveloperDir,
+    'Applications',
+    'Simulator.app',
+  );
+  const deviceHubApp = path.join(
+    activeDeveloperDir,
+    '..',
+    'Applications',
+    'DeviceHub.app',
+  );
+
+  if (fs.existsSync(simulatorApp)) {
+    child_process.execFileSync('open', [
+      simulatorApp,
+      '--args',
+      '-CurrentDeviceUDID',
+      simulator.udid,
+    ]);
+  } else if (fs.existsSync(deviceHubApp)) {
+    child_process.execFileSync('open', [
+      `devices://device/open?id=${simulator.udid}`,
+    ]);
+  }
 
   if (simulator.state !== 'Booted') {
     bootSimulator(simulator);