diff --git a/Makefile.nanvix b/Makefile.nanvix
index 12706137a3206f2..68e79fd7b0cf0b4 100644
--- a/Makefile.nanvix
+++ b/Makefile.nanvix
@@ -156,15 +156,7 @@ CONFIGURE_ENV = \
 	CFLAGS="-L$(SYSROOT_PATH)/lib -I$(SYSROOT_PATH)/include" \
 	CFLAGS_NODIST="-fno-semantic-interposition" \
 	LDFLAGS="-T$(SYSROOT_PATH)/lib/user.ld -Wl,--allow-multiple-definition -Wl,-pie -Wl,--export-dynamic -Wl,--no-dynamic-linker" \
-	LIBS="-Wl,--start-group $(LIBPOSIX) $(LIBC) $(LIBM) -lsqlite3 -lssl -lcrypto -lz -lbz2 -lffi -Wl,--end-group" \
-	LIBSQLITE3_LIBS="-L$(SYSROOT_PATH)/lib -lsqlite3" \
-	LIBSQLITE3_CFLAGS="-I$(SYSROOT_PATH)/include" \
-	ZLIB_LIBS="-L$(SYSROOT_PATH)/lib -lz" \
-	ZLIB_CFLAGS="-I$(SYSROOT_PATH)/include" \
-	BZIP2_LIBS="-L$(SYSROOT_PATH)/lib -lbz2" \
-	BZIP2_CFLAGS="-I$(SYSROOT_PATH)/include" \
-	LIBFFI_LIBS="-L$(SYSROOT_PATH)/lib -lffi" \
-	LIBFFI_CFLAGS="-I$(SYSROOT_PATH)/include"
+	LIBS="-Wl,--start-group $(LIBPOSIX) $(LIBC) $(LIBM) -Wl,--end-group"
 
 # Configure options for Nanvix
 CONFIGURE_OPTS = \
@@ -180,7 +172,6 @@ CONFIGURE_OPTS = \
 	--exec-prefix="$(INSTALL_PREFIX)" \
 	--with-ensurepip=no \
 	--with-pkg-config=no \
-	--with-openssl="$(SYSROOT_PATH)" \
 	--disable-ipv6 \
 	ac_cv_file__dev_ptmx=no \
 	ac_cv_file__dev_ptc=no \
diff --git a/Modules/Setup.local b/Modules/Setup.local
new file mode 100644
index 000000000000000..191670ab1cbde1a
--- /dev/null
+++ b/Modules/Setup.local
@@ -0,0 +1,48 @@
+# Disable non-essential C extension modules to reduce binary size.
+# All stdlib .py files remain in the sysroot; only the C accelerators
+# are excluded from the statically-linked binary.
+
+*disabled*
+_decimal
+unicodedata
+_ctypes
+_sqlite3
+_ssl
+_codecs_cn
+_codecs_hk
+_codecs_iso2022
+_codecs_jp
+_codecs_kr
+_codecs_tw
+_multibytecodec
+pyexpat
+_elementtree
+_posixsubprocess
+select
+_socket
+_asyncio
+_pickle
+_json
+math
+cmath
+_statistics
+_datetime
+_bz2
+binascii
+array
+_bisect
+_contextvars
+_csv
+_heapq
+_opcode
+_queue
+_random
+_struct
+_zoneinfo
+_md5
+_sha1
+_sha256
+_sha512
+_sha3
+_blake2
+zlib