diff --git a/src/instana/instrumentation/werkzeug.py b/src/instana/instrumentation/werkzeug.py
index 5e4e96bc..366a3b33 100644
--- a/src/instana/instrumentation/werkzeug.py
+++ b/src/instana/instrumentation/werkzeug.py
@@ -100,6 +100,34 @@ def run_simple_with_instana(
 
         return wrapped(*args, **kwargs)
 
+    @wrapt.patch_function_wrapper("werkzeug.serving", "BaseWSGIServer.__init__")
+    def base_wsgi_server_init_with_instana(
+        wrapped: Callable,
+        instance: Any,
+        args: tuple,
+        kwargs: dict[str, Any],
+    ) -> Any:
+        """
+        Patch werkzeug.serving.BaseWSGIServer.__init__ to wrap WSGI applications.
+
+        Covers frameworks like Odoo that instantiate BaseWSGIServer (or its
+        subclasses such as ThreadedWSGIServer) directly without going through
+        run_simple.  The app is wrapped after super().__init__ so that any
+        subclass setup that reads self.app also sees the instrumented version.
+        """
+        wrapped(*args, **kwargs)
+        try:
+            if _is_flask_app(instance.app):
+                logger.debug("Skipping BaseWSGIServer instrumentation for Flask app")
+                return
+            if not isinstance(instance.app, InstanaWSGIMiddleware):
+                instance.app = InstanaWSGIMiddleware(
+                    instance.app, status_as_string=False
+                )
+                logger.debug("BaseWSGIServer app wrapped")
+        except Exception:
+            logger.debug("Failed to wrap BaseWSGIServer app", exc_info=True)
+
     logger.debug("Instrumenting werkzeug")
 
 except ImportError:
diff --git a/tests/frameworks/test_werkzeug.py b/tests/frameworks/test_werkzeug.py
index f7865c59..de9b6250 100644
--- a/tests/frameworks/test_werkzeug.py
+++ b/tests/frameworks/test_werkzeug.py
@@ -601,6 +601,68 @@ def __call__(self, environ, start_response):
             assert call_args[2] is flask_app
             assert not isinstance(call_args[2], InstanaWSGIMiddleware)
 
+    def test_base_wsgi_server_direct_instantiation(self) -> None:
+        """Test instrumentation when BaseWSGIServer is instantiated directly (e.g. Odoo).
+
+        Odoo's ThreadedWSGIServerReloadable extends werkzeug.serving.ThreadedWSGIServer
+        which extends BaseWSGIServer, bypassing run_simple entirely. This test verifies
+        that the BaseWSGIServer.__init__ patch wraps the app in that case.
+        """
+        import socket
+        from werkzeug.serving import BaseWSGIServer
+
+        with socket.socket(socket.AF_INET, socket.SOCK_STREAM) as s:
+            s.bind(("127.0.0.1", 0))
+            port = s.getsockname()[1]
+
+        server = BaseWSGIServer("127.0.0.1", port, simple_wsgi_app)
+        try:
+            assert isinstance(server.app, InstanaWSGIMiddleware)
+            assert server.app.app is simple_wsgi_app
+        finally:
+            server.server_close()
+
+    def test_base_wsgi_server_skips_flask_app(self) -> None:
+        """Test that BaseWSGIServer patch skips Flask apps."""
+        import socket
+        from werkzeug.serving import BaseWSGIServer
+
+        class Flask:
+            def __call__(self, environ, start_response):
+                return simple_wsgi_app(environ, start_response)
+
+        Flask.__module__ = "flask.app"
+        flask_app = Flask()
+
+        with socket.socket(socket.AF_INET, socket.SOCK_STREAM) as s:
+            s.bind(("127.0.0.1", 0))
+            port = s.getsockname()[1]
+
+        server = BaseWSGIServer("127.0.0.1", port, flask_app)
+        try:
+            assert server.app is flask_app
+            assert not isinstance(server.app, InstanaWSGIMiddleware)
+        finally:
+            server.server_close()
+
+    def test_base_wsgi_server_not_double_wrapped(self) -> None:
+        """Test that an already-wrapped app is not wrapped again."""
+        import socket
+        from werkzeug.serving import BaseWSGIServer
+
+        pre_wrapped = InstanaWSGIMiddleware(simple_wsgi_app, status_as_string=False)
+
+        with socket.socket(socket.AF_INET, socket.SOCK_STREAM) as s:
+            s.bind(("127.0.0.1", 0))
+            port = s.getsockname()[1]
+
+        server = BaseWSGIServer("127.0.0.1", port, pre_wrapped)
+        try:
+            assert server.app is pre_wrapped
+            assert not isinstance(server.app.app, InstanaWSGIMiddleware)
+        finally:
+            server.server_close()
+
 
 def test_parse_status_code_handles_valid_and_invalid_values() -> None:
     """Test safe parsing of WSGI status strings."""